منابع مشابه
ELT: A Trojan Horse in Disguise?
Many people believe that language teaching is a neutral practice. However, this belief is not without its own opponents. To many scholars, teaching languages cannot be devoid of teaching cultural values of the target language, which tacitly aims at denigrating cultural values of the community of the learners who are learning it. The ultimate purpose of such cultural oppression, according to the...
متن کاملDNA PK JBC 110713 final
The resection of DNA double strand breaks (DSBs) initiates homologous recombination (HR) and is critical for genomic stability. Using direct measurement of resection in human cells and reconstituted assays of resection with purified proteins in vitro, we show that DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a classic non-homologous end joining (NHEJ) factor, antagonizes DSB resec...
متن کاملVisualization of a DNA-PK/PARP1 complex
The DNA-dependent protein kinase (DNA-PK) and Poly(ADP-ribose) polymerase-1 (PARP1) are critical enzymes that reduce genomic damage caused by DNA lesions. They are both activated by DNA strand breaks generated by physiological and environmental factors, and they have been shown to interact. Here, we report in vivo evidence that DNA-PK and PARP1 are equally necessary for rapid repair. We purifie...
متن کاملDNA-PK Deficiency in Alzheimer's Disease.
Alzheimer's disease (AD) is characterized by neuronal death with an accumulaton of intra-cellular neurofibrillary tangles (NFT) and extracellular amyloid plaques. Reduced DNA repair ability has been reported in AD brains. In neurons, the predominant mechanism to repair double-strand DNA breaks (DSB) is non-homologous end joining (NHEJ) that requires DNA-dependent protein kinase (DNA-PK) activit...
متن کاملMDC1 regulates DNA-PK autophosphorylation in response to DNA damage.
DNA damage initiates signaling events through kinase cascades that result in cell cycle checkpoint control and DNA repair. However, it is not yet clear how the signaling pathways relay to DNA damage repair. Using the repeat region of checkpoint protein MDC1 (mediator of DNA damage checkpoint protein 1), we identified DNA-PKcs/Ku as MDC1-associated proteins. Here, we show that MDC1 directly inte...
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ژورنال
عنوان ژورنال: Journal of Cell Signaling
سال: 2018
ISSN: 2576-1471
DOI: 10.4172/2576-1471.1000184